Categoría: Adult Stem Cells
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How Inflammation Suppresses Stem Cell Function
Wang et al. PLoS One;5(12):e14206. Low grade inflammation is well known to correlate with development of numerous disease conditions such as heart failure, kidney failure, and diabetes. It is generally accepted that oxidative stress caused by inflammation is one of the means by which disease evolution occurs. Inflammatory conditions usually generate oxygen free radicals that…
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What Works Better: Stem Cell Mobilization or Stem Cell Administration for Brain Injury
Bakhtiary et al. Iran Biomed J. 2010 Oct;14(4):142-9. Bone marrow mobilization is used as part of hematopoietic stem cell transplantation in order to collect donor bone marrow stem cells without having to puncture the bone. The process of mobilization is induced by administration of the drug G-CSF, which is approved by the FDA. One interesting…
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Scientists identify and isolate adult mammary stem cells in mice
(Times of India) It is well-known that stem cells exist in adult tissues. The most commonly known stem cell, the bone marrow stem cell, plays the physiological role of generating billions of blood cells per hour while being capable of making copies of itself. Subsequent to the discovery of the bone marrow stem cell in…
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Stem cell therapy benefits patients with chronic heart failure—study
(Neharika Sabharwal) After a heart attack the myocardium (heart muscle) undergoes a period of damage during which cells of the body attempt to heal the injured tissue. This occurs through stem cells found in the heart itself, called cardiac specific stem cells (CSC) as well as bone marrow stem cells which seem to exit the…
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Immunomodulation of Delayed-Type Hypersensitivity Responses by Mesenchymal Stem Cells Is Associated with Bystander T Cell Apoptosis in the Draining Lymph Node.
(Lim et al. J Immunol) Immune responses are quantified in many ways. Typically one thinks about immunity as the ability of an organism to overcome infection with another organism. However this test is impossible to perform in a reproducible, quantitative, and ethical way in humans. An alternative test was developed by immunologists called delayed type…
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Platelet-Rich Plasma Releasate Promotes Differentiation of Tendon Stem Cells Into Active Tenocytes.
(Zhang et al. Am J Sports Med. ) Platelet rich plasma (PRP) contains products of activated platelets which include numerous growth factors such as fibroblast growth factor, hepatocyte growth factor, insulin like growth factor, etc. Conventionally, PRP is used to promote various healing processes. In the area of sports medicine PRP has been used for…
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Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study.
Liang et al. Ann Rheum Dis. 2010 Aug;69(8):1423-9. Mesenchymal stem cells are unique in that on the one hand they are capable of differentiating into a variety of tissues, but on the other hand they also are potently anti-inflammatory and immune modulatory. Evidence of immune modulation comes from studies that show mesenchymal stem cells: a)…
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Stem Cells for Spinal Cord Injury
The use of mesenchymal stem cells for a variety have diseases has been published. This includes conditions such as heart failure, liver failure, stroke, and lupus. One of the attractive features of mesenchymal stem cells is that they can differentiate into numerous tissues while at the same time exerting anti-inflammatory activities. In the situation of…
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Protein Found on Endometrial Regenerative Cells Inhibits Immune Attack
Medistem Inc. (PINKSHEETS: MEDS) announced today publication of a peer reviewed paper identifying a molecule found on the company’s lead product, the universal donor Endometrial Regenerative Cell (ERC), as a key component of cellular escape from immune attack. The study, entitled “Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated…
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Medistem Reports Rheumatoid Arthritis Patient Success Using Adult Stem Cell Protocol
SAN DIEGO, CA – (Marketwire – June 21, 2010) – Medistem Inc. Medistem Inc. together with the Stem Cell Institute reported today publication in the peer reviewed journal Cellular Immunology its paper titled «Autologous stromal vascular fraction cells: A tool for facilitating tolerance in rheumatic disease,» which describes the first use of a patient’s own…