Categoría: Stem Cell Research
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Blood Vessels Made from Embryonic Stem Cells are Different than Naturally Occurring Blood Vessels
Glaser et al. J Vasc Res. 2011 May 31;48(5):415-428. In addition to ethical dilemmas associated with embryonic stem cells, there are ample data demonstrating at administration of these cells causes formation of aggressive tumors called teratomas. One way in which scientists are trying to “tame” these cells is to reprogram them in the test tube.…
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How Bone Marrow Stem Cells Help in Stroke Recovery
Nakano-Doi et al. Stem Cells 28(7):1292-302. May 2011 Scientists from the Institute for Advanced Medical Sciences of Hyogo, Japan have announced new research findings suggesting that bone marrow stem cells may be useful in the treatment of stroke. Although other scientists have previously demonstrated similar findings, including in patients, (Suárez-Monteagudo et al. Restor Neurol Neurosci.…
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Stem cell therapy gives dogs new pep in their step
Linda Goldston, lgoldston@mercurynews.com Mercury News Cookie is a thirteen year-old Australian shepherd mix that has been having increasing trouble lying down and getting up. She could not walk down stairs and even during normal walks around the park her legs would give out. Cookie’s master, Ed Tani of Hayward was terrified that Cookie’s days were…
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Bone Marrow Stem Cells Successful For Liver Failure Caused by Hepatitis B
Peng et al. Hepatology. The liver is the most regenerative solid organ in the body. One can resect 2/3 of the liver and it will still regenerate back to normal size. There have been several experimental studies in animals where induction of liver injury is treated by administration of bone marrow stem cells. A video…
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Mimicking Human Diseases in Cells: iPS Cells Used to Create Model of Extremely Rare Condition Dyskeratosis Congenita
Batista et al. Nature. Key to scientific progress is the ability to test new treatments in animals that represent the human disease of interest or in cells in the laboratory that represent the human disease. The better these test systems represent the human disease, the more likely it is that approaches successful in the test…
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Killing of the iPS Field?
Zhao et al. Nature. Embryonic stem cells are associated with numerous ethical dilemmas. The creation of equivalents of ES cells through retrodifferentiation led to a new area of research that does not require destruction of life. Specifically, it was discovered that any adult cell can be transfected with several genes, which results in the cell…
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Where Cord Matrix Stem Cells Go After Injection
Maurya et al. World J Stem Cells. 2011 Apr 26;3(4):34-42. Stem cell migration is a very relevant issue when discussing the systemic administration of stem cells as therapeutics. There is a widely held belief that intravenous administration of stem cells results in accumulation into the lungs and liver. While studies have demonstrated that stem cells…
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Bone Marrow Stem Cells Protect Lungs from Herbicide Injury
Yang et al. Clin Toxicol (Phila). 2011 Apr;49(4):298-302. Paraquat is a herbicide that is linked to development of Parkinsons. It also is a toxin to lung cells and is used as a model of inducing lung injury in rats. In the current study the investigators wanted to see if administration of bone marrow mesenchymal stem…
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Stem Cell trial volunteers thank doctors at reunion lunch
Miami Herald, by Fred Tasker, ftasker@MiamiHerald.com Stem cell therapy was originally used for the treatment of leukemias in the form of bone marrow transplant. Nearly 2 decades after this groundbreaking work, clinical trials initiated using bone marrow stem cells for treatment of heart patients. Bone marrow stem cells possess the ability to stimulate new blood…
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Forcing Stem Cells into Circulation Results in Protection from Liver Failure in Animals
Zhang et al. Toxicol Lett. While previous studies showed that administration of bone marrow cells are capable of repairing livers in animal and human studies, relatively little work has been performed to augment existing means by which the body uses its own stem cells to heal the liver. Specifically, it has been demonstrated that in…