Categoría: Stem Cell Research
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Magnetic Attraction of Stem Cells to Injured Heart Creates Potent Treatment
The intracoronary administration of bone marrow stem cells in patients who have suffered a heart attack has been demonstrated to cause beneficial effects in double blind studies, as discussed in this video http://www.youtube.com/watch?v=flv0RmzPyLU. Intracoronary administration has potential side effects since a balloon needs to be expanded in the area where the heart attack occurred, which…
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Using Stem Cells to Study Alcohol Dependence
One of the major advancements in the area of stem cell research has been the establishment of techniques for "retro-differentiating" of old cells into younger cells. Perhaps one of the best examples of this is the discovery by the Japanese group of Yamanaka the skin cells can be coaxed to take the resemblance of embryonic…
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Can A Nutritional Supplement Grow Stem Cells?
The Center for Improvement of Human Functioning International (CIHFI) was lead author on a peer reviewed study published in the Journal of Translational Medicine http://www.translational-medicine.com/content/pdf/1479-5876-8-34.pdf describing how Stem-Kine, a commercially available nutritional supplement, significantly elevated levels of two types of stem cells in circulation. This appears to be the first publication in the peer-reviewed literature…
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Cord Blood Stem Cell Therapy for Cerebral Palsy in Clinical Trial
Cerebral palsy is characterized by hypoxia/reperfusion induced damaged to the brain in the perinatal period. It is manifested in four main types: a) Spastic, which occurs in 70-80% of cases and is associated with damage to the corticospinal tract or the motor cortex; b) Ataxic, occurs in 10%, is associated with damage to the cerebrum,…
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Stem cell therapy shows early promise: Celgene
Crohn’s disease is a favorite amongst mesenchymal stem cell development companies. This may be because on the one hand, this type of stem cell possesses anti-inflammatory properties, and on the other hand it has the potential to regenerate injured tissue. Additionally since the quality of life of patients with advanced Crohn’s Disease is so poor,…
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Histostem Works With Korean Government Agency to Provide Cord Blood Storage for Multicultural Families
The US company Amstem through subsidiary signed a partnership agreement with the Songpa-Gu Office of the Seoul Metropolitan Government, to provide umbilical cord blood banking to multicultural families for up to 15 years. Cord blood is currently used for treatment of patients with blood disorders such as leukemias as an alternative to bone marrow. Unfortunately…
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Stem Cell Treatment for Heart Attacks: Timing is Everything
Skeletal myoblasts are a type of muscle-specific stem cell that have been used previously in several clinical trials, particularly for heart failure and post-heart attack patients. Advantages of this type of stem cell include the fact that they are from adult sources (no risk of cancer), they are already committed to becoming muscle cells, and…
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Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes
Generation of inducible pluripotent stem cells (iPS) offers the possibility of creating patient-specific stem cells with embryonic stem cell therapeutic potential from adult sources. Recently the main hurdle of iPS cell generation, the need for introduction of oncogenes in the adult cells, has been removed by use of chemical modulators as well as alternative non-cancer…
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The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
Embryonic stem cells possess the ability to propagate in tissue culture indefinitely. This is different than differentiated cells, for example, skin cells which can only multiple in tissue culture approximately 50 times before undergoing senescence. The ability of embryonic stem cells to escape senescence is related to expression of the protein telomerase. Usually when cells…
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Cord blood stem cells help meet minority marrow needs
Leukemias are cancers of the cells that give rise to white blood cells. For example in myeloid leukemias the cells that normally would become the blood cells neutrophils or macrophages start to make copies of themselves but refuse to mature. What happens is that the body is flooding with cells that on the one hand…