Categoría: Stem Cell Research
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Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study.
Liang et al. Ann Rheum Dis. 2010 Aug;69(8):1423-9. Mesenchymal stem cells are unique in that on the one hand they are capable of differentiating into a variety of tissues, but on the other hand they also are potently anti-inflammatory and immune modulatory. Evidence of immune modulation comes from studies that show mesenchymal stem cells: a)…
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Pluripotent stem cell-derived natural killer cells for cancer therapy.
Knorr et al. Transl Res. 2010 Sep;156(3):147-154. Epub Immune therapy of cancer is an exciting prospect given the possibility of treating cancer without the side effects associated with conventional treatments such as chemotherapy or radiotherapy. Additionally, the use of the immune system to target tumors offers the possibility of eradicating micrometastasis, which often cannot be…
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Stem Cells for Spinal Cord Injury
The use of mesenchymal stem cells for a variety have diseases has been published. This includes conditions such as heart failure, liver failure, stroke, and lupus. One of the attractive features of mesenchymal stem cells is that they can differentiate into numerous tissues while at the same time exerting anti-inflammatory activities. In the situation of…
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Protein Found on Endometrial Regenerative Cells Inhibits Immune Attack
Medistem Inc. (PINKSHEETS: MEDS) announced today publication of a peer reviewed paper identifying a molecule found on the company’s lead product, the universal donor Endometrial Regenerative Cell (ERC), as a key component of cellular escape from immune attack. The study, entitled “Resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated…
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Eradication of brain tumor stem cells with an oncolytic adenovirus.
Jiang et al. Discov Med. 2010 Jul;10(50):24-8. Philosophically, tumor cells have an advantage to humans in the “War on Cancer”. That is, the tumors have the ability to rapidly mutate, so that when drugs are given to fight the tumor, the tumor can “mutate around” the drug and become resistant. This occurs in several ways:…
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Medistem Reports Rheumatoid Arthritis Patient Success Using Adult Stem Cell Protocol
SAN DIEGO, CA – (Marketwire – June 21, 2010) – Medistem Inc. Medistem Inc. together with the Stem Cell Institute reported today publication in the peer reviewed journal Cellular Immunology its paper titled «Autologous stromal vascular fraction cells: A tool for facilitating tolerance in rheumatic disease,» which describes the first use of a patient’s own…
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Pluristem’s Off-The-Shelf Placenta-Derived Cell Therapies
Pluristem announced that its "off the shelf" placental stem cells will be the focus of upcoming talking at investor and medical conferences. The company Pluristem is currently in Phase I trials assessing its unique bio-reactor expanded placental stem cells for the treatment of critical limb ischemia. In contrast to other therapies that use the patient’s…
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Identification of Peptides Which Show Potential To Generate Cancer Stem Cell Specific Immune Responses
The use of the immune system to target cancer has been a therapeutic goal for over a century. The advantage of immunotherapy is the possibility of targeting cancer throughout the body in a non-toxic manner, thus allowing destruction of metastasis, and induction of immunological memory to protect from relapse. Unfortunately with exception of the recent…
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Success Stems From Adult Cells
The use of adult stem cells for conditions besides bone marrow transplant is most prevalent in the area of heart failure. Since the original study of Strauer et al in 2001 in which a 46-year old patient was administered bone marrow stem cells after a heart attack and experienced a profound improvement in cardiac function,…
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Stem Cells Restore Tissue Affected By Acute Lung Injury
Researchers from the University of California San Francisco presented data today at the ATS 2010 International Conference in New Orleans demonstrating activity of adult stem cells in treatment of acute lung injury. This is a common condition in intensive care units that causes respiratory failure and often leads to death. The cause of acute lung…